Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.

H, Ding; S, Chen; X, Pan; X, Dai; G, Pan; Z, Li; X, Mai; Y, Tian; S, Zhang; B, Liu; G, Cao; Z, Yao; X, Yao; L, Gao; L, Yang; X, Chen; J, Sun; H, Chen; M, Han; Y, Yin; G, Xu; H, Li; W, Wu; Z, Chen; J, Lin; L, Xiang; J, Hu; Y, Lu; X, Zhu; L, Xie

doi:10.1002/jcsm.12700

Public

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.

Shared by NobleBlocks on May 6, 2021 • 12:00 AM UTC

Authors:

Ding H

Chen S

Pan X

Abstract

<h4>Background</h4>Satellite cells (SCs) are critical to skeletal muscle regeneration. Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle-specific deletion of Tfr1 results in growth retardation, metabolic disorder, a...

Subject

Satellite Cells

Tfr1

Ferroptosis

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