Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Pazoki, Raha; Vujkovic, Marijana; Elliott, Joshua; Evangelou, Evangelos; Gill, Dipender; Ghanbari, Mohsen; J. van der Most, Peter; Climaco Pinto, Rui; Wielscher, Matthias; Farlik, Matthias; Zuber, Verena; J. de Knegt, Robert; Snieder, Harold; G. Uitterlinden, André; Cohort Study, Lifelines; Marike Boezen, H.; Franke, Lude; van der Harst, Pim; Navis, Gerjan; Rots, Marianne; Swertz, Morris; H. R. Wolffenbuttel, Bruce; Wijmenga, Cisca; A. Lynch, Julie; Jiang, Xiyun; Said, Saredo; E. Kaplan, David; Min Lee, Kyung; Serper, Marina; M. Carr, Rotonya; S. Tsao, Philip; R. Atkinson, Stephen; Dehghan, Abbas; Tzoulaki, Ioanna; Arfan Ikram, M.; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Z. Alizadeh, Behrooz; J. O’Donnell, Christopher; Saleheen, Danish; F. Voight, Benjamin; Chang, Kyong-Mi; R. Thursz, Mark; Elliott, Paul; VA Million Veteran Program, the; K. Ballas, Zuhair; Bhushan, Sujata; J. Boyko, Edward; M. Cohen, David; Concato, John; Aslan, Michaela; Zhao, Hongyu; I. Constans, Joseph; J. Dellitalia, Louis; M. Fayad, Joseph; S. Fernando, Ronald; J. Florez, Hermes; A. Gaddy, Melinda; S. Gappy, Saib; Gibson, Gretchen; Godschalk, Michael; A. Greco, Jennifer; Gupta, Samir; Gutierrez, Salvador; D. Hammer, Kimberly; B. Hamner, Mark; B. Harley, John; M. Hung, Adriana; Huq, Mostaqul; A. Hurley, Robin; R. Iruvanti, Pran; J. Ivins, Douglas; J. Jacono, Frank; N. Jhala, Darshana; S. Kaminsky, Laurence; B. Klein, Jon; Liangpunsakul, Suthat; H. Lichy, Jack; Moser, Jennifer; D. Huang, Grant; Muralidhar, Sumitra; M. Mastorides, Stephen; O. Mathew, Roy; M. Mattocks, Kristin; McArdle, Rachel; N. Meyer, Paul; J. Meyer, Laurence; P. Moorman, Jonathan; R. Morgan, Timothy; Murdoch, Maureen; O. Okusaga, Olaoluwa; K. Oursler, Kris-Ann; R. Ratcliffe, Nora; I. Rauchman, Michael; Brooks Robey, R.; W. Ross, George; J. Servatius, Richard; C. Sharma, Satish; E. Sherman, Scott; Sonel, Elif; Sriram, Peruvemba; Stapley, Todd; T. Striker, Robert; Tandon, Neeraj; Villareal, Gerardo; S. Wallbom, Agnes; M. Wells, John; C. Whittle, Jeffrey; A. Whooley, Mary; W. Wilson, Peter; V. Sun, Yan; Xu, Junzhe; Yeh, Shing-Shing; Connor, Todd; P. Argyres, Dean; R. Hauser, Elizabeth; C. Beckham, Jean; Stephens, Brady; M. Aguayo, Samuel; K. Ahuja, Sunil; Pyarajan, Saiju; Cho, Kelly; Michael Gaziano, J.; Kinlay, Scott; T. Nguyen, Xuan-Mai; V. Brewer, Jessica; T. Brophy, Mary; V. Do, Nhan; E. Humphries, Donald; E. Selva, Luis; Shayan, Shahpoor; B. Whitbourne, Stacey; L. Breeling, Jim; P. Casas Romero, J.; B. Ramoni, Rachel

doi:10.1038/s41467-021-22338-2

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Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Shared by NobleBlocks on May 10, 2021 • 12:00 AM UTC

Authors:

Raha Pazoki

Marijana Vujkovic

Joshua Elliott

Abstract

Abstract Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank particip...

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