API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing

D. Johnson, Martin; L. Burcham, Christopher; A. May, Scott; R. Calvin, Joel; McClary Groh, Jennifer; S. Myers, Steven; P. Webster, Luke; C. Roberts, Jeffrey; Venkata Ramana Reddy, G.; V. Luciani, Carla; P. Corrigan, Aoife; D. Spencer, Richard; Moylan, Robert; A. Boyse, Raymond; D. Murphy, John; R. Stout, James

doi:10.1021/acs.oprd.0c00345

Public

API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing

Shared by NobleBlocks on May 16, 2021 • 12:00 AM UTC

Authors:

Martin D. Johnson

Christopher L. Burcham

Scott A. May

Abstract

Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished continuously using a cascade of mixed suspension mixed product removal crystallizers in cGMP manufacturing. This article describes the journey taken to transform a set of technical to final batch crystallizations in...

Subject

Crystallization

Process engineering

Active ingredient

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!