Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration.

Y, Lei; L, Tang; S, Liu; S, Hu; L, Wu; Y, Liu; M, Yang; S, Huang; X, Tang; T, Tang; X, Zhao; I, Vlodavsky; S, Zeng; B, Tang; S, Yang

doi:10.1186/s40168-021-01065-2

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Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration.

Shared by NobleBlocks on May 20, 2021 • 12:00 AM UTC

Authors:

Lei Y

Tang L

Liu S

Abstract

<h4>Background</h4>The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of heparanase in acute pancreatitis remain poorly understood. Here, we investigated the...

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