Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis.

D, Gill; V, Zuber; J, Dawson; J, Pearson-Stuttard; AR, Carter; E, Sanderson; V, Karhunen; MG, Levin; RE, Wootton; D, Klarin; PS, Tsao; KK, Tsilidis; SM, Damrauer; S, Burgess; P, Elliott

doi:10.1038/s41366-021-00807-4

Public

Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis.

Shared by NobleBlocks on May 17, 2021 • 12:00 AM UTC

Authors:

Gill D

Zuber V

Dawson J

Abstract

<h4>Background</h4>Higher body mass index (BMI) and waist-to-hip ratio (WHR) increase the risk of cardiovascular disease, but the extent to which this is mediated by blood pressure, diabetes, lipid traits, and smoking is not fully understood.<h4>Methods</h4>Using consortia and UK Biobank genetic ass...

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