Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations

A. A. Saleh, Mohammed; Fong Loo, Chi; Elassaiss-Schaap, Jeroen; C. M. De Lange, Elizabeth

doi:10.1007/s10928-021-09768-7

Public

Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations

Published in Journal of Pharmacokinetics and Pharmacodynamics • Jun 17, 2021

Authors:

Mohammed A. A. Saleh

Chi Fong Loo

Jeroen Elassaiss-Schaap

Abstract

Abstract Predicting brain pharmacokinetics is critical for central nervous system (CNS) drug development yet difficult due to ethical restrictions of human brain sampling. CNS pharmacokinetic (PK) profiles are often altered in CNS diseases due to disease-specific pathophysiology. We previously publi...

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