Mapping the human genetic architecture of COVID-19

Host Genetics Initiative, COVID-19; Host Genetics InitiativeLeadership, COVID-19; E. K. Niemi, Mari; Karjalainen, Juha; G. Liao, Rachel; M. Neale, Benjamin; Daly, Mark; Ganna, Andrea; group, Writing; group leaders, Writing; A. Pathak, Gita; J. Andrews, Shea; Kanai, Masahiro; group members, Writing; Veerapen, Kumar; Fernandez-Cadenas, Israel; C. Schulte, Eva; Striano, Pasquale; Marttila, Minttu; Minica, Camelia; Marouli, Eirini; Anisul Karim, Mohd; R. Wendt, Frank; Savage, Jeanne; Sloofman, Laura; Butler-Laporte, Guillaume; Kim, Han-Na; Kanoni, Stavroula; Okada, Yukinori; Byun, Jinyoung; Han, Younghun; Jashim Uddin, Mohammed; Davey Smith, George; J. Willer, Cristen; D. Buxbaum, Joseph; group, Analysis; analyses team leader, Manuscript; analyses team member: meta-analysis, Manuscript; Mehtonen, Juha; analyses team member: heritability, methods and supplements, Manuscript; analyses team member: PHEWAS, Manuscript; analyses team member: Mendelian randomization, Manuscript; analyses team member: PC projection and gene prioritization, Manuscript; analyses team member: gene prioritization, Manuscript; Finucane, Hilary; analyses team member: sensitivity analysis, Manuscript; Cordioli, Mattia; analyses team members: PC projection, Manuscript; R. Martin, Alicia; Zhou, Wei; silico analysis team members, In; Pasaniuc, Bogdan; Julienne, Hanna; Aschard, Hugues; Shi, Huwenbo; Yengo, Loic; Polimanti, Renato; Ghoussaini, Maya; Schwartzentruber, Jeremy; Dunham, Ian; management group, Project; management leader, Project; management support, Project; Chwialkowska, Karolina; Francescatto, Margherita; Trankiem, Amy; K. Balaconis, Mary; steering group, Phenotype; Davis, Lea; Lee, Sulggi; Priest, James; Renieri, Alessandra; G. Sankaran, Vijay; van Heel, David; Deelen, Patrick; Brent Richards, J.; Nakanishi, Tomoko; Biesecker, Les; Eric Kerchberger, V.; Kenneth Baillie, J.; dictionary, Data; Mari, Francesca; Bernasconi, Anna; Ceri Baillie, Stefano; Canakoglu, Arif; communication group, Scientific; communication leaders, Scientific; Wolford, Brooke; communication members, Scientific; Faucon, Annika; Kumar Dutta, Atanu; Schurmann, Claudia; Harry, Emi; Birney, Ewan; Nguyen, Huy; Nasir, Jamal; Kaunisto, Mari; Solomonson, Matthew; Dueker, Nicole; Vadgama, Nirmal; Limou, Sophie; , Translators; Rahmouni, Souad; Mbarek, Hamdi; Darwish, Dima; Mesbah Uddin, Md; Albertos, Raquel; Pérez-Tur, Jordi; Li, Ruolin; Folkersen, Lasse; Moltke, Ida; Koelling, Nils; Teumer, Alexander; Kousathanas, Athanasios; Utrilla, Alicia; A. Verdugo, Ricardo; Zárate, Ruth; Medina-Gómez, Carolina; Gómez-Cabrero, David; Carnero-Montoro, Elena; L. Cadilla, Carmen; Moreno-Estrada, Andrés; Garmendia, Adriana; Moya, Leire; Sedaghati-Khayat, Bahar; Romuald Boua, Palwendé; Favé, Marie-Julie; Francioli, Laurent; Lemaçon, Audrey; Migeotte, Isabelle; Patel, Sanjay; Varnai, Reka; L. Szentpeteri, Jozsef; Sipeky, Csilla; Colombo, Francesca; von Hohenstaufen, Kathrin; Lio, Pietro; Vallerga, Costanza; Wang, Qingbo; Tanigawa, Yosuke; Im, Hogune; Han, Chulho; Song, Han; Lim, Jiwoo; Lee, Younhe; Kim, Sugyeong; Im, Sangyoon; Atanasovska, Biljana; Fauzan Ahmad, Hajar; Boer, Cindy; Jansen, Philip; Franke, Lude; Kaja, Elżbieta; Pasko, Dorota; Kennis-Szilagyi, Ingrid; A. Kornilov, Sergey; Prijatelj, Vid; Prokić, Ivana; Sivanadhan, Ilangkumaran; Perumal, Sarala; Esmaeeli, Sahar; M. Pearson, Nathaniel; Development, Website; development leaders, Website; , 23andMe; team leader, Analysis; Auton, Adam; collection leaders, Data; COVID-19 Team*, 23andMe; F. Shelton, Janie; J. Shastri, Anjali; team members, Analysis; Filshtein-Sonmez, Teresa; Coker, Daniella; Symons, Antony; Esparza-Gordillo, Jorge; Aslibekyan, Stella; O’Connell, Jared; collection members, Data; Ye, Chelsea; H. Weldon, Catherine; COVID-19 Team, 23andMe; , ACCOuNT; team leader, Analysis; Perera, Minoli; collection leaders, Data; O’Leary, Kevin; Tuck, Matthew; O’Brien, Travis; Meltzer, David; O’Donnell, Peter; Nutescu, Edith; team members, Analysis; Yang, Guang; collection members, Data; Alarcon, Cristina; Herrmann, Stefanie; Mazurek, Sophia; Banagan, Jeff; Hamidi, Zacharia

doi:10.1038/s41586-021-03767-x

Public

Mapping the human genetic architecture of COVID-19

Shared by NobleBlocks on Jul 8, 2021 • 12:00 AM UTC

Authors:

COVID-19 Host Genetics Initiative

COVID-19 Host Genetics InitiativeLeadership

Mari E. K. Niemi

Abstract

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important. Identifying...

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