Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations

M. Merritt, Jeremy; V. Borkar, Indrakant; Y. Buser, Jonas; Campbell Brewer, Alison; Campos, Odilon; A. Fleming, Jeffrey; Hansen, Caoimhe; Humenik, Ashley; Jeffery, S.P.; B. Kokitkar, Prashant; P. Kolis, Stanley; B. Forst, Mindy; R. Lambertus, Gordon; R. Martinelli, Joseph; McCartan, Ciaran; Moursy, Hossam; B. Murphy, Donal; M. Murray, Michael; O’Donnell, K.P.; G. O’Sullivan, Rita; A. Richardson, Gary; Xia, Han

doi:10.1021/acs.oprd.1c00198

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Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations

Shared by NobleBlocks on Aug 6, 2021 • 12:00 AM UTC

Authors:

Jeremy M. Merritt

Indrakant V. Borkar

Jonas Y. Buser

Abstract

The hazard assessment of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis(pinacolato)diboron (BisPin), used in the developmental synthesis of an intermediate for abemaciclib, led to the observation of hydrogen being generated. Quantitative headspace GC and solution 11B NMR ...

Subject

Borylation

Reagent

Scope (computer science)

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