Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).

KM, Thomson; C, Dyer; F, Liu; K, Sands; E, Portal; MJ, Carvalho; M, Barrell; I, Boostrom; S, Dunachie; R, Farzana; A, Ferreira; F, Frayne; B, Hassan; E, Jones; L, Jones; J, Mathias; R, Milton; J, Rees; GJ, Chan; D, Bekele; A, Mahlet; S, Basu; RK, Nandy; B, Saha; K, Iregbu; F, Modibbo; S, Uwaezuoke; R, Zahra; H, Shirazi; NU, Syed; JB, Mazarati; A, Rucogoza; L, Gaju; S, Mehtar; ANH, Bulabula; A, Whitelaw; Hasselt JGC, van; TR, Walsh

doi:10.1016/s1473-3099(21)00050-5

Public

Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).

Shared by NobleBlocks on Aug 9, 2021 • 12:00 AM UTC

Authors:

Thomson KM

Dyer C

Liu F

Abstract

<h4>Background</h4>Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and a...

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