Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.

RA, García; JA, Lupisella; BR, Ito; MY, Hsu; G, Fernando; NL, Carson; JJ, Allocco; CS, Ryan; R, Zhang; Z, Wang; M, Heroux; M, Carrier; S, St-Onge; M, Bouvier; S, Dudhgaonkar; J, Nagar; MM, Bustamante-Pozo; A, Garate-Carrillo; J, Chen; X, Ma; DJ, Search; EA, Dierks; EK, Kick; RR, Wexler; DA, Gordon; J, Ostrowski; NR, Wurtz; F, Villarreal

doi:10.1016/j.jacbts.2021.07.007

Public

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction.

Shared by NobleBlocks on Aug 23, 2021 • 12:00 AM UTC

Authors:

García RA

Lupisella JA

Ito BR

Abstract

Dysregulated inflammation following myocardial infarction (MI) leads to maladaptive healing and remodeling. The study characterized and evaluated a selective formyl peptide receptor 2 (FPR2) agonist BMS-986235 in cellular assays and in rodents undergoing MI. BMS-986235 activated G proteins and promo...

Subject

Resolution

Myocardial infarction

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