Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.

KM, Hastie; H, Li; D, Bedinger; SL, Schendel; SM, Dennison; K, Li; V, Rayaprolu; X, Yu; C, Mann; M, Zandonatti; Avalos R, Diaz; D, Zyla; T, Buck; S, Hui; K, Shaffer; C, Hariharan; J, Yin; E, Olmedillas; A, Enriquez; D, Parekh; M, Abraha; E, Feeney; GQ, Horn; Y, Aldon; H, Ali; S, Aracic; RR, Cobb; RS, Federman; JM, Fernandez; J, Glanville; R, Green; G, Grigoryan; Hernandez AG, Lujan; DD, Ho; KA, Huang; J, Ingraham; W, Jiang; P, Kellam; C, Kim; M, Kim; HM, Kim; C, Kong; SJ, Krebs; F, Lan; G, Lang; S, Lee; CL, Leung; J, Liu; Y, Lu; A, MacCamy; AT, McGuire; AL, Palser; TH, Rabbitts; Tehrani Z, Rikhtegaran; MM, Sajadi; RW, Sanders; AK, Sato; L, Schweizer; J, Seo; B, Shen; JL, Snitselaar; L, Stamatatos; Y, Tan; MT, Tomic; Gils MJ, van; S, Youssef; J, Yu; TZ, Yuan; Q, Zhang; B, Peters; GD, Tomaras; T, Germann; EO, Saphire

doi:10.1126/science.abh2315

Public

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.

Shared by NobleBlocks on Sep 23, 2021 • 12:00 AM UTC

Authors:

Hastie KM

Li H

Bedinger D

Abstract

Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Multiple mutations in SARS-CoV-2 that could impair antibody defenses propagated in human-to-human transmission and spillover...

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