A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

N, Magusali; AC, Graham; TM, Piers; P, Panichnantakul; U, Yaman; M, Shoai; RH, Reynolds; JA, Botia; KJ, Brookes; T, Guetta-Baranes; E, Bellou; S, Bayram; D, Sokolova; M, Ryten; Frigerio C, Sala; V, Escott-Price; K, Morgan; JM, Pocock; J, Hardy; DA, Salih

doi:10.1093/brain/awab337

Public

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.

Published in Brain : a journal of neurology • Dec 1, 2021

Authors:

Magusali N

Graham AC

Piers TM

Abstract

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia. However, the function of OAS1 within microglia was not known. Using genotyping from 1313 individuals with sporadic Alzheimer'...

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Open Access

Subject

Interferon

Microglia

Alzheimer’s disease

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