A prenylated dsRNA sensor protects against severe COVID-19.

A, Wickenhagen; E, Sugrue; S, Lytras; S, Kuchi; M, Noerenberg; ML, Turnbull; C, Loney; V, Herder; J, Allan; I, Jarmson; N, Cameron-Ruiz; M, Varjak; RM, Pinto; JY, Lee; L, Iselin; N, Palmalux; DG, Stewart; S, Swingler; EJD, Greenwood; TWM, Crozier; Q, Gu; EL, Davies; S, Clohisey; B, Wang; Maranhão Costa F, Trindade; Santana M, Freire; Lima Ferreira LC, de; L, Murphy; A, Fawkes; A, Meynert; G, Grimes; Silva Filho JL, Da; M, Marti; J, Hughes; RJ, Stanton; ECY, Wang; A, Ho; I, Davis; RF, Jarrett; A, Castello; DL, Robertson; MG, Semple; PJM, Openshaw; M, Palmarini; PJ, Lehner; JK, Baillie; SJ, Rihn; SJ, Wilson

doi:10.1126/science.abj3624

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A prenylated dsRNA sensor protects against severe COVID-19.

Shared by NobleBlocks on Oct 29, 2021 • 12:00 AM UTC

Authors:

Wickenhagen A

Sugrue E

Lytras S

Abstract

Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses releva...

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