Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects.

S, Mirzaei; MH, Gholami; F, Hashemi; A, Zabolian; MV, Farahani; K, Hushmandi; A, Zarrabi; A, Goldman; M, Ashrafizadeh; G, Orive

doi:10.1016/j.drudis.2021.09.020

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Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects.

Shared by NobleBlocks on Oct 6, 2021 • 12:00 AM UTC

Authors:

Mirzaei S

Gholami MH

Hashemi F

Abstract

P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, to reveal their participation in DOX resistance. These antitumor compounds an...

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