High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.

MJ, Russo; CD, Orru; L, Concha-Marambio; S, Giaisi; BR, Groveman; CM, Farris; B, Holguin; AG, Hughson; DE, LaFontant; C, Caspell-Garcia; CS, Coffey; J, Mollon; SJ, Hutten; K, Merchant; RG, Heym; C, Soto; B, Caughey; UJ, Kang

doi:10.1186/s40478-021-01282-8

Public

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson's disease.

Shared by NobleBlocks on Nov 6, 2021 • 12:00 AM UTC

Authors:

Russo MJ

Orru CD

Concha-Marambio L

Abstract

Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson's disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and other sy...

Subject

alpha-Synuclein

Parkinson’s Disease

Synucleinopathy

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