RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

RA-MAP Consortium, The; D. Isaacs, John; Brockbank, Sarah; Wakatsuki Pedersen, Ayako; Hilkens, Catharien; Anderson, Amy; Stocks, Philip; Lendrem, Dennis; Tarn, Jessica; R. Smith, Graham; Allen, Ben; Casement, John; Diboll, Julie; Harry, Rachel; A. H. Cooles, Faye; P. Cope, Andrew; Simpson, Gemma; Toward, Ruth; Noble, Hayley; Parke, Angela; Wu, Wing; Clarke, Fiona; Scott, David; C. Scott, Ian; Galloway, James; Lempp, Heidi; Ibrahim, Fowzia; Schwank, Samana; Molyneux, Gemma; Lazarov, Tomi; Geissmann, Frederic; S. Goodyear, Carl; B. McInnes, Iain; Donnelly, Iona; Gilmour, Ashley; Tulunay Virlan, Aysin; Porter, Duncan; Ponchel, Frederique; Emery, Paul; El-Jawhari, Jehan; Parmar, Rekha; F. McDermott, Michael; A. Fisher, Benjamin; P. Young, Steve; Jones, Philip; Raza, Karim; Filer, Andrew; Pitzalis, Costantino; R. Barnes, Michael; S. Watson, David; Henkin, Rafael; Thorborn, Georgina; Fossati-Jimack, Liliane; Kelly, Stephen; Humby, Frances; Bombardieri, Michele; Rana, Sharmila; Jia, Zhilong; Goldmann, Katriona; Lewis, Myles; Ng, Sandra; Barbosa-Silva, Adriano; Tzanis, Evan; Gallagher-Syed, Amaya; R. John, Christopher; R. Ehrenstein, Michael; Altobelli, Gioia; Martins, Sandra; Nguyen, Dao; Ali, Humayara; Ciurtin, Coziana; Buch, Maya; Symmons, Deborah; Worthington, Jane; N. Bruce, Ian; C. Sergeant, Jamie; M. M. Verstappen, Suzanne; Stirling, Fiona; Hughes-Morley, Adwoa; Tom, Brian; Farewell, Vernon; Zhong, Yujie; C. Taylor, Peter; D. Buckley, Christopher; Keidel, Sarah; Cuff, Carolyn; Levesque, Marc; Long, Andrew; Liu, Zheng; Lipsky, Samantha; Harvey, Bohdan; Macoritto, Michael; Hong, Feng; Kaymakcalan, Sukru; Tsuji, Wayne; Sabin, Tony; Ward, Neil; Talbot, Susan; Padhji, Desmond; Sleeman, Matthew; Finch, Donna; Herath, Athula; Lindholm, Catharina; Jenkins, Martin; Ho, Meilien; Hollis, Sally; Marshall, Chris; Parker, Gerry; Page, Matt; Edwards, Hannah; Cuza, Alexandru; Gozzard, Neil; Pandis, Ioannis; Rowe, Anthony; Bonachela Capdevila, Francisco; J. Loza, Matthew; Curran, Mark; Verbeeck, Denny; Baker, Dan; M. Mela, Christopher; Vranic, Ivana; T. Mela, Catherine; Wright, Stephen; Rowell, Lucy; Vernon, Emma; Joseph, Nina; Payne, Neil; Rao, Ravi; Binks, Michael; Belson, Alexandra; Ludbrook, Valerie; Hicks, Kirsty; Tipney, Hannah; Ellis, Joanne; Hasan, Samiul; Didierlaurent, Arnaud; Burny, Wivine; Haynes, Andrea; Larminie, Chris; Harris, Ray; Dastros-Pitei, Daniela; Carini, Claudio; Kola, Blerina; Jelinsky, Scott; Hodge, Martin; Maciejewski, Mateusz; Ziemek, Daniel; Schulz-Knappe, Peter; Zucht, Hans-Dieter; Budde, Petra; Coles, Mark; A. Butler, James; Read, Simon

doi:10.1038/s41597-022-01264-y

Public

RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients

Shared by NobleBlocks on May 9, 2022 • 12:00 AM UTC

Authors:

The RA-MAP Consortium

John D. Isaacs

Sarah Brockbank

Abstract

Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehen...

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