Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

SW, Syversen; KK, Jørgensen; GL, Goll; MK, Brun; Ø, Sandanger; KH, Bjørlykke; J, Sexton; IC, Olsen; JE, Gehin; DJ, Warren; RA, Klaasen; G, Noraberg; TJ, Bruun; CK, Dotterud; MKA, Ljoså; AJ, Haugen; RJ, Njålla; C, Zettel; CM, Ystrøm; YH, Bragnes; S, Skorpe; T, Thune; KA, Seeberg; B, Michelsen; IM, Blomgren; EK, Strand; P, Mielnik; R, Torp; C, Mørk; TK, Kvien; J, Jahnsen; N, Bolstad; EA, Haavardsholm

doi:10.1001/jama.2021.21316

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Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

Shared by NobleBlocks on Dec 1, 2021 • 12:00 AM UTC

Authors:

Syversen SW

Jørgensen KK

Goll GL

Abstract

<h4>Importance</h4>Proactive therapeutic drug monitoring (TDM), consisting of individualized treatment based on scheduled assessments of serum drug levels, has been proposed as an alternative to standard therapy to optimize efficacy and safety of infliximab and other biologic drugs. However, it rema...

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