The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders

P. Luís, João; J. V. Simões, Carlos; M. M. Brito, Rui

doi:10.3390/ijms23031731

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The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders

Published in International Journal of Molecular Sciences • Feb 2, 2022

Authors:

João P. Luís

Carlos J. V. Simões

Rui M. M. Brito

Abstract

The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the "epicenter" of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune response in the central nervous system (CNS) during injury ...

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Open Access

Subject

Neuroinflammation

Central nervous system

Neuroscience

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