Caloric restriction in humans reveals immunometabolic regulators of health span.

O, Spadaro; Y, Youm; I, Shchukina; S, Ryu; S, Sidorov; A, Ravussin; K, Nguyen; E, Aladyeva; AN, Predeus; SR, Smith; E, Ravussin; C, Galban; MN, Artyomov; VD, Dixit

doi:10.1126/science.abg7292

Public

Caloric restriction in humans reveals immunometabolic regulators of health span.

Shared by NobleBlocks on Feb 10, 2022 • 12:00 AM UTC

Authors:

Spadaro O

Youm Y

Shchukina I

Abstract

The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis a...

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