Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

A, Aggarwal; R, Liu; Y, Chen; AJ, Ralowicz; SJ, Bergerson; F, Tomaska; TL, Hanson; JP, Hasseman; D, Reep; G, Tsegaye; P, Yao; X, Ji; M, Kloos; D, Walpita; R, Patel; MA, Mohr; PW, Tilberg; B, Mohar; LL, Looger; JS, Marvin; MB, Hoppa; A, Konnerth; D, Kleinfeld; ER, Schreiter; K, Podgorski

doi:10.1101/2022.02.13.480251

Public

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

Shared by NobleBlocks on Feb 15, 2022 • 12:00 AM UTC

Authors:

Aggarwal A

Liu R

Chen Y

Abstract

The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with genetic and molecular specificity. However, existing iGluSnFR variants exhibit saturating activation kinetics and are excluded from post-synaptic densities, limiting their ability to distinguish synaptic from extr...

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