Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

Jia, Mengping; Li, Qinhan; Guo, Jieyu; Shi, Weihao; Zhu, Lei; Huang, Yijun; Li, Yongbo; Wang, Li; Ma, Siyu; Zhuang, Tao; Wang, Xiaoqun; Pan, Qi; Wei, Xiangxiang; Qin, Yue; Li, Xiaobo; Jin, Jiayu; Zhi, Xiuling; Tang, Jingdong; Jing, Qing; Li, Shanqun; Jiang, Lindi; Qu, Lefeng; Osto, Elena; Zhang, Jianyi; Wang, Xinhong; Yu, Bo; Meng, Dan

doi:10.1161/circresaha.121.319540

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Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

Shared by NobleBlocks on Apr 1, 2022 • 12:00 AM UTC

Authors:

Mengping Jia

Qinhan Li

Jieyu Guo

Abstract

Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the ischemic hindlimbs of adult mice. However, the role and underlying mechanisms of BACH1 in atherosclerosis remain unclear. Methods: Mouse...

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