Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.

XM, Ma; K, Geng; BY, Law; P, Wang; YL, Pu; Q, Chen; HW, Xu; XZ, Tan; ZZ, Jiang; Y, Xu

doi:10.1007/s10565-021-09692-z

Public

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes.

Shared by NobleBlocks on Mar 2, 2022 • 12:00 AM UTC

Authors:

Ma XM

Geng K

Law BY

Abstract

Diabetic cardiomyopathy (DCM) is characterized by lipid accumulation, mitochondrial dysfunction, and aseptic inflammatory activation. Mitochondria-derived cytosolic DNA has been reported to induce inflammation by activating cyclic GMP-AMP synthase (cGAS)/the stimulator of interferon genes (STING) pa...

Subject

Diabetic cardiomyopathy

Lipotoxicity

Cgas-sting

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