Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Morales Berstein, Fernanda; L McCartney, Daniel; T Lu, Ake; K Tsilidis, Konstantinos; Bouras, Emmanouil; Haycock, Philip; Burrows, Kimberley; I Phipps, Amanda; D Buchanan, Daniel; Cheng, Iona; PRACTICAL consortium, the; M Martin, Richard; Davey Smith, George; L Relton, Caroline; Horvath, Steve; E Marioni, Riccardo; G Richardson, Tom; C Richmond, Rebecca

doi:10.7554/elife.75374

Public

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

Shared by NobleBlocks on Mar 28, 2022 • 12:00 AM UTC

Authors:

Fernanda Morales Berstein

Daniel L McCartney

Ake T Lu

Abstract

Background: Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker. Methods: We conducted a two-sample Mendelian randomization (MR) study to examine ...

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