Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

P, Georg; R, Astaburuaga-García; L, Bonaguro; S, Brumhard; L, Michalick; LJ, Lippert; T, Kostevc; C, Gäbel; M, Schneider; M, Streitz; V, Demichev; I, Gemünd; M, Barone; P, Tober-Lau; ET, Helbig; D, Hillus; L, Petrov; J, Stein; HP, Dey; D, Paclik; C, Iwert; M, Mülleder; SK, Aulakh; S, Djudjaj; RD, Bülow; HE, Mei; AR, Schulz; A, Thiel; S, Hippenstiel; AE, Saliba; R, Eils; I, Lehmann; MA, Mall; S, Stricker; J, Röhmel; VM, Corman; D, Beule; E, Wyler; M, Landthaler; B, Obermayer; Stillfried S, von; P, Boor; M, Demir; H, Wesselmann; N, Suttorp; A, Uhrig; H, Müller-Redetzky; J, Nattermann; WM, Kuebler; C, Meisel; M, Ralser; JL, Schultze; AC, Aschenbrenner; C, Thibeault; F, Kurth; LE, Sander; N, Blüthgen; B, Sawitzki

doi:10.1016/j.cell.2021.12.040

Public

Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

Published in Cell • Dec 28, 2021

Authors:

Georg P

Astaburuaga-García R

Bonaguro L

Abstract

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell func...

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Open Access

Subject

Cytotoxicity

Complement

T cells

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