The Genomic Landscapes of Human Breast and Colorectal Cancers

D. Wood, Laura; Williams Parsons, D.; Jones, Siân; Lin, Jimmy; Sjöblom, Tobias; J. Leary, Rebecca; Shen, Dong; M. Boca, Simina; Barber, Thomas; Ptak, Janine; Silliman, Natalie; Szabo, Steve; Dezso, Zoltan; Ustyanksky, Vadim; Nikolskaya, Tatiana; Nikolsky, Yuri; Karchin, Rachel; A. Wilson, Paul; S. Kaminker, Joshua; Zhang, Zemin; Croshaw, Randal; Willis, Joseph; Dawson, Dawn; Shipitsin, Michail; K. V. Willson, James; Sukumar, Saraswati; Polyak, Kornelia; Ho Park, Ben; L. Pethiyagoda, Charit; V. Krishna Pant, P.; G. Ballinger, Dennis; B. Sparks, Andrew; Hartigan, James; R. Smith, Douglas; Suh, Erick; Papadopoulos, Nickolas; Buckhaults, Phillip; D. Markowitz, Sanford; Parmigiani, Giovanni; W. Kinzler, Kenneth; E. Velculescu, Victor; Vogelstein, Bert

doi:10.1126/science.1145720

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The Genomic Landscapes of Human Breast and Colorectal Cancers

Shared by NobleBlocks on Nov 16, 2007 • 12:00 AM UTC

Authors:

Laura D. Wood

D. Williams Parsons

Siân Jones

Abstract

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in the...

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