Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.

X, Gong; J, Du; SH, Parsons; FF, Merzoug; Y, Webster; PW, Iversen; LC, Chio; Horn RD, Van; X, Lin; W, Blosser; B, Han; S, Jin; S, Yao; H, Bian; C, Ficklin; L, Fan; A, Kapoor; S, Antonysamy; Nulty AM, Mc; K, Froning; D, Manglicmot; A, Pustilnik; K, Weichert; SR, Wasserman; M, Dowless; C, Marugán; C, Baquero; MJ, Lallena; SW, Eastman; YH, Hui; MZ, Dieter; T, Doman; S, Chu; HR, Qian; XS, Ye; DA, Barda; GD, Plowman; C, Reinhard; RM, Campbell; JR, Henry; SG, Buchanan

doi:10.1158/2159-8290.cd-18-0469

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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.

Shared by NobleBlocks on Oct 29, 2018 • 12:00 AM UTC

Authors:

Gong X

Du J

Parsons SH

Abstract

Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To identify drugs synthetic lethal with RB1 mutation (RB1 mut), we tested 36 cell-cycle inhib...

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene.

Abstract

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