Mendelian randomization for studying the effects of perturbing drug targets

Gill, Dipender; K. Georgakis, Marios; Walker, Venexia; F. Schmidt, Amand; Gkatzionis, Apostolos; F. Freitag, Daniel; Finan, Chris; D. Hingorani, Aroon; M. M. Howson, Joanna; Burgess, Stephen; I. Swerdlow, Daniel; Davey Smith, George; V. Holmes, Michael; Dichgans, Martin; Zheng, Jie; M. Psaty, Bruce; M Davies, Neil

doi:10.12688/wellcomeopenres.16544.1

Public

Mendelian randomization for studying the effects of perturbing drug targets

Published in Wellcome Open Research • Jan 28, 2021

Authors:

Dipender Gill

Marios K. Georgakis

Venexia Walker

Abstract

<ns4:p>Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to ...

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Open Access

Subject

Mendelian randomization

Mendelian inheritance

Drug

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