Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Murai, Hiroki; Kodama, Takahiro; Maesaka, Kazuki; Tange, Shoichiro; Motooka, Daisuke; Suzuki, Yutaka; Shigematsu, Yasuyuki; Inamura, Kentaro; Mise, Yoshihiro; Saiura, Akio; Ono, Yoshihiro; Takahashi, Yu; Kawasaki, Yota; Iino, Satoshi; Kobayashi, Shogo; Idogawa, Masashi; Tokino, Takashi; Hashidate‐Yoshida, Tomomi; Shindou, Hideo; Miyazaki, Masanori; Imai, Yasuharu; Tanaka, Satoshi; Mita, Eiji; Ohkawa, Kazuyoshi; Hikita, Hayato; Sakamori, Ryotaro; Tatsumi, Tomohide; Eguchi, Hidetoshi; Morii, Eiichi; Takehara, Tetsuo

doi:10.1002/hep.32573

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Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Shared by NobleBlocks on Jun 17, 2022 • 12:00 AM UTC

Authors:

Hiroki Murai

Takahiro Kodama

Kazuki Maesaka

Abstract

Background and Aims: Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its efficacy remains limited. To identify immunotherapy‐susceptible HCC, we profiled the molecular abnormalities and tumor immune microenvironment (TIME) of rapidly increasing nonvira...

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