FOXP3 exon 2 controls T
            <sub>reg</sub>
            stability and autoimmunity

Du, Jianguang; Wang, Qun; Yang, Shuangshuang; Chen, Si; Fu, Yongyao; Spath, Sabine; Domeier, Phillip; Hagin, David; Anover-Sombke, Stephanie; Haouili, Maya; Liu, Sheng; Wan, Jun; Han, Lei; Liu, Juli; Yang, Lei; Sangani, Neel; Li, Yujing; Lu, Xiongbin; Chandra Janga, Sarath; H. Kaplan, Mark; R. Torgerson, Troy; F. Ziegler, Steven; Zhou, Baohua

doi:10.1126/sciimmunol.abo5407

Public

FOXP3 exon 2 controls T <sub>reg</sub> stability and autoimmunity

Shared by NobleBlocks on Jun 24, 2022 • 12:00 AM UTC

Authors:

Jianguang Du

Qun Wang

Shuangshuang Yang

Abstract

Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3 encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) containing all the coding exons and a shorter isoform lacking the amino acids encoded by exon 2 (FOXP3 ΔE2). The two isoforms are...

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