The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum.

CP, Sanchez; EDT, Manson; Cubel S, Moliner; L, Mandel; SK, Weidt; MP, Barrett; M, Lanzer

doi:10.1128/spectrum.01101-22

Public

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum.

Shared by NobleBlocks on Jul 18, 2022 • 12:00 AM UTC

Authors:

Sanchez CP

Manson EDT

Moliner Cubel S

Abstract

The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the digestive vacuole of the parasite, where hemoglobin taken up by the parasite from its host cell is degraded. PfCRT can ...

Subject

Malaria

Substrate

Oligopeptides

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