T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals.

N, Philipp; M, Kazerani; A, Nicholls; B, Vick; J, Wulf; T, Straub; M, Scheurer; A, Muth; G, Hänel; D, Nixdorf; M, Sponheimer; M, Ohlmeyer; SM, Lacher; B, Brauchle; A, Marcinek; L, Rohrbacher; A, Leutbecher; K, Rejeski; O, Weigert; Bergwelt-Baildon M, von; S, Theurich; R, Kischel; I, Jeremias; V, Bücklein; M, Subklewe

doi:10.1182/blood.2022015956

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T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals.

Published in Blood • Sep 1, 2022

Authors:

Philipp N

Kazerani M

Nicholls A

Abstract

T-cell-recruiting bispecific molecule therapy has yielded promising results in patients with hematologic malignancies; however, resistance and subsequent relapse remains a major challenge. T-cell exhaustion induced by persistent antigen stimulation or tonic receptor signaling has been reported to co...

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