Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease

Dong, An-qi; Yang, Ya-ping; Jiang, Shu-min; Yao, Xiao-yu; Qi, Di; Mao, Cheng-jie; Cheng, Xiao-yu; Wang, Fen; Hu, Li-fang; Liu, Chun-feng

doi:10.1038/s41401-022-00951-1

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Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease

Shared by NobleBlocks on Jul 27, 2022 • 12:00 AM UTC

Authors:

An-qi Dong

Ya-ping Yang

Shu-min Jiang

Abstract

Abstract Inflammation is one of the pathogenic processes in Parkinson’s disease (PD). Dopamine receptor agonist pramipexole (PPX) is extensively used for PD treatment in clinics. A number of studies show that PPX exerts neuroprotection on dopaminergic (DA) neurons, but the molecular mechanisms under...

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