Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA.

R, Zhang; Y, Zhang; F, Guo; G, Huang; Y, Zhao; B, Chen; C, Wang; C, Cui; Y, Shi; S, Li; H, Cui

doi:10.1038/s41420-022-01220-0

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Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA.

Shared by NobleBlocks on Oct 28, 2022 • 12:00 AM UTC

Authors:

Zhang R

Zhang Y

Guo F

Abstract

N6-methyladenosine (m<sup>6</sup>A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contribu...

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