Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Born, Emmanuelle; Lipskaia, Larissa; Breau, Marielle; Houssaini, Amal; Beaulieu, Delphine; Marcos, Elisabeth; Pierre, Remi; Do Cruzeiro, Marcio; Lefevre, Marine; Derumeaux, Genevieve; V. Bulavin, Dmitry; Delcroix, Marion; Quarck, Rozenn; Reen, Virinder; Gil, Jesus; Bernard, David; Flaman, Jean-Michel; Adnot, Serge; Abid, Shariq

doi:10.1161/circulationaha.122.058794

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Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Shared by NobleBlocks on Feb 21, 2023 • 12:00 AM UTC

Authors:

Emmanuelle Born

Larissa Lipskaia

Marielle Breau

Abstract

Background: Senescent cells (SCs) are involved in proliferative disorders, but their role in pulmonary hypertension remains undefined. We investigated SCs in patients with pulmonary arterial hypertension and the role of SCs in animal pulmonary hypertension models. Methods: We investigated senescence...

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