Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

DS, Reynolds; TW, Rosahl; J, Cirone; GF, O'Meara; A, Haythornthwaite; RJ, Newman; J, Myers; C, Sur; O, Howell; AR, Rutter; J, Atack; AJ, Macaulay; KL, Hadingham; PH, Hutson; D, Belelli; JJ, Lambert; GR, Dawson; R, McKernan; PJ, Whiting; KA, Wafford

doi:10.1523/jneurosci.23-24-08608.2003

Public

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience • Sep 1, 2003

Authors:

Reynolds DS

Rosahl TW

Cirone J

Abstract

The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA(A) receptors, with selectivity for beta2 and beta3 subunit-containing receptors determined by a single asparagine residue. We generated a genetically mo...

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