Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

M. Ritzel, Rodney; Li, Yun; Jiao, Yun; Lei, Zhuofan; J. Doran, Sarah; He, Junyun; A. Shahror, Rami; J. Henry, Rebecca; Khan, Romeesa; Tan, Chunfeng; Liu, Shaolin; A. Stoica, Bogdan; I. Faden, Alan; Szeto, Gregory; J. Loane, David; Wu, Junfang

doi:10.1126/sciadv.add1101

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Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

Shared by NobleBlocks on Mar 10, 2023 • 12:00 AM UTC

Authors:

Rodney M. Ritzel

Yun Li

Yun Jiao

Abstract

Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old...

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