Niraparib with Abiraterone Acetate and Prednisone for Metastatic Castration-Resistant Prostate Cancer: Phase II QUEST Study Results.

KN, Chi; N, Fleshner; VE, Chiuri; Bruwaene S, Van; J, Hafron; DG, McNeel; Porre P, De; RS, Maul; M, Daksh; X, Zhong; GE, Mason; RF, Tutrone

doi:10.1093/oncolo/oyad008

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Niraparib with Abiraterone Acetate and Prednisone for Metastatic Castration-Resistant Prostate Cancer: Phase II QUEST Study Results.

Shared by NobleBlocks on May 1, 2023 • 12:00 AM UTC

Authors:

Chi KN

Fleshner N

Chiuri VE

Abstract

Niraparib (NIRA) is a highly selective inhibitor of poly (adenosine diphosphate-ribose) polymerase, PARP1 and PARP2, which play a role in DNA repair. The phase II QUEST study evaluated NIRA combinations in patients with metastatic castration-resistant prostate cancer who were positive for homologous...

Subject

Castration-resistant Prostate Cancer

Abiraterone Acetate

Parp Inhibitor

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