Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.

Laboute, Thibaut; Zucca, Stefano; Holcomb, Matthew; N Patil, Dipak; Garza, Chris; A Wheatley, Brittany; N Roy, Raktim; Forli, Stefano; A Martemyanov, Kirill

doi:10.1126/science.add7150

Public

Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.

Shared by NobleBlocks on Mar 31, 2023 • 12:00 AM UTC

Authors:

Thibaut Laboute

Stefano Zucca

Matthew Holcomb

Abstract

Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein-coupled receptor, GPR158, as a metabotropic glycine receptor (mGlyR). Glyc...

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