GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Pairo-Castineira, Erola; Rawlik, Konrad; D. Bretherick, Andrew; Qi, Ting; Wu, Yang; Nassiri, Isar; A. McConkey, Glenn; Zechner, Marie; Klaric, Lucija; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Richmond, Anne; Millar, Jonathan; D. Russell, Clark; Malinauskas, Tomas; Thwaites, Ryan; Morrice, Kirstie; Keating, Sean; Maslove, David; Nichol, Alistair; G. Semple, Malcolm; Knight, Julian; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; J. M. Openshaw, Peter; Begg, Colin; Walsh, Timothy; Tenesa, Albert; Flores, Carlos; A. Riancho, José; Rojas-Martinez, Augusto; Lapunzina, Pablo; Investigators, GenOMICC; , Co-Investigators; Clohisey, Sara; Millar, Johnny; Shankar-Hari, Manu; Laboratory and Data Team, Management,; Aitkin, Emma; Aravindan, Latha; Armstrong, Ruth; Kenneth Baillie, J.; Biggs, Heather; Boz, Ceilia; Brown, Adam; Chikowore, Primmy; Clark, Richard; Coutts, Audrey; Coyle, Judy; Cullum, Louise; Das, Sukamal; Day, Nicky; Donnelly, Lorna; Duncan, Esther; Finernan, Paul; Head Fourman, Max; Furlong, Anita; Furniss, James; Gallagher, Bernadette; Gilchrist, Tammy; Golightly, Ailsa; Griffiths, Fiona; Hafezi, Katarzyna; Hamilton, Debbie; Hendry, Ross; Kearns, Naomi; Law, Dawn; Law, Rachel; Law, Sarah; Lidstone-Scott, Rebecca; Lauder, Christen; Macgillivray, Louise; Maclean, Alan; Mal, Hanning; McCafferty, Sarah; McMaster, Ellie; Meikle, Jen; C. Moore, Shona; Murphy, Sheena; Mybaya, Hellen; Odam, Miranda; Oosthuyzen, Wilna; Zheng, Chenqing; Chen, Jiantao; Parkinson, Nick; Paterson, Trevor; Tucker, Petra; Schon, Katherine; Stenhouse, Andrew; Das, Mihaela; Swets, Maaike; Szoor-McElhinney, Helen; Taneski, Filip; Turtle, Lance; Wackett, Tony; Ward, Mairi; Weaver, Jane; Wrobel, Nicola; Zechner, Marie; and St Thomas’ Hospital, London, UK, Guys; Pan, Jacqueline; Grau, Neus; Owen Jones, Tim; Lim, Rosario; Marotti, Martina; Whitton, Christopher; Bociek, Aneta; Campos, Sara; Arbane, Gill; Shankar-Hari, Manu; Ostermann, Marlies; Cha, Mina; DAmato, Fabiola; Kosifidou, Eirini; Lorah, Shelley; Morera, Kyma; Cook University Hospital, Middlesbrough, UK, James; Bircham, Sarah; Brady, Laura; Hugill, Keith; Henning, Jeremy; Bonner, Stephen; Headlam, Evie; Jones, Jessica; List, Abigail; Morley, Joanne; Welford, Amy; Kamangu, Bobette; Ratnakumar, Anitha; Shoremekun, Abiola; Health NHS Trust, London, UK, Barts; Alldis, Zoe; Astin-Chamberlain, Raine; Bibi, Fatima; Biddle, Jack; Blow, Sarah; Bolton, Matthew; Borra, Catherine; Bowles, Ruth; Burton, Maudrian; Choudhury, Yasmin; Cox, Amber; Easthope, Amy; Ebano, Patrizia; Fotiadis, Stavros; Gurasashvili, Jana; Halls, Rosslyn; Hartridge, Pippa; Kallon, Delordson; Kassam, Jamila; Lancoma-Malcolm, Ivone; Matharu, Maninderpal; May, Peter; Mitchelmore, Oliver; Newman, Tabitha; Patel, Mital; Pheby, Jane; Pinzuti, Irene; Prime, Zoe; Prysyazhna, Oleksandra; Shiel, Julian; Taylor, Melanie; Tierney, Carey; Zongo, Olivier; Wood, Suzanne; Zak, Anne; Collier, David; Stoke University Hospital, Staffordshire, UK, Royal; Mundy, Manuela; Thompson, Christopher; Pritchard, Lisa; Gellamucho, Minnie; Cartlidge, David; Bandla, Nageswar; Bailey, Lucy; Davies, Michelle; Delaney, Jane; Scott, Leanne; Middlesex University Hospital NHS trust, London, UK, North; Abdelrazik, Marwa; Alasdair, Frater; Carter, David; Elhassan, Munzir; Ganesan, Arunkumar; Jenkins, Samuel; Lamond, Zoe; Purohit, Dharam; Rohit, Kumar; Saleem, Malik; Wall, Alanna; Xavier, Kugan; Bakthavatsalam, Dhanalaksmi; Gehad, Kirolos; Gnanapragasam, Pakeerathan

doi:10.1038/s41586-023-06034-3

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Shared by NobleBlocks on May 17, 2023 • 12:00 AM UTC

Authors:

Erola Pairo-Castineira

Konrad Rawlik

Andrew D. Bretherick

Abstract

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who ar...

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