Evaluation and Management of Deficiency of Adenosine Deaminase 2

Y. Lee, Pui; A. Davidson, Brad; S. Abraham, Roshini; Alter, Blanche; I. Arostegui, Juan; Bell, Katherine; Belot, Alexandre; R. E. Bergerson, Jenna; J. Bernard, Timothy; A. Brogan, Paul; Berkun, Yackov; T. Deuitch, Natalie; Dimitrova, Dimana; A. Georgin-Lavialle, Sophie; Gattorno, Marco; Grimbacher, Bodo; Hashem, Hasan; S. Hershfield, Michael; N. Ichord, Rebecca; Izawa, Kazushi; A. Kanakry, Jennifer; P. Khubchandani, Raju; C.C. Klouwer, Femke; A. Luton, Evan; W. Man, Ada; Meyts, Isabelle; M. Van Montfrans, Joris; Ozen, Seza; Saarela, Janna; C. Santo, Gustavo; Sharma, Aman; Soldatos, Ariane; Sparks, Rachel; R. Torgerson, Troy; Leandro Uriarte, Ignacio; A. B. Youngstein, Taryn; Zhou, Qing; Aksentijevich, Ivona; L. Kastner, Daniel; P. Chambers, Eugene; K. Ombrello, Amanda; Foundation, DADA2; K. Makley, Mary; L. Hayner, Kristen; E. Kling, Bridget; M. Cowsert, Lex; S. Williams, Julie

doi:10.1001/jamanetworkopen.2023.15894

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Evaluation and Management of Deficiency of Adenosine Deaminase 2

Shared by NobleBlocks on May 28, 2023 • 12:00 AM UTC

Authors:

Pui Y. Lee

Brad A. Davidson

Roshini S. Abraham

Abstract

Importance Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited disease characterized by systemic vasculitis, early-onset stroke, bone marrow failure, and/or immunodeficiency affecting both children and adults. DADA2 is among the more common monogenic autoinflammatory diseases, wit...

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