Preoperative Treatment of Locally Advanced Rectal Cancer.

D, Schrag; Q, Shi; MR, Weiser; MJ, Gollub; LB, Saltz; BL, Musher; J, Goldberg; Baghdadi T, Al; KA, Goodman; RR, McWilliams; JM, Farma; TJ, George; HF, Kennecke; A, Shergill; M, Montemurro; GD, Nelson; B, Colgrove; V, Gordon; AP, Venook; EM, O'Reilly; JA, Meyerhardt; AC, Dueck; E, Basch; GJ, Chang; HJ, Mamon

doi:10.1056/nejmoa2303269

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Preoperative Treatment of Locally Advanced Rectal Cancer.

Published in The New England journal of medicine • Jun 4, 2023

Authors:

Schrag D

Shi Q

Weiser MR

Abstract

<h4>Background</h4>Pelvic radiation plus sensitizing chemotherapy with a fluoropyrimidine (chemoradiotherapy) before surgery is standard care for locally advanced rectal cancer in North America. Whether neoadjuvant chemotherapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) can be used in l...

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