Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.

Moliner, Rafael; Girych, Mykhailo; A Brunello, Cecilia; Kovaleva, Vera; Biojone, Caroline; Enkavi, Giray; Antenucci, Lina; F Kot, Erik; A Goncharuk, Sergey; Kaurinkoski, Katja; Kuutti, Mirjami; M Fred, Senem; V Elsilä, Lauri; Sakson, Sven; Cannarozzo, Cecilia; R A F Diniz, Cassiano; Seiffert, Nina; Rubiolo, Anna; Haapaniemi, Hele; Meshi, Elsa; Nagaeva, Elina; Öhman, Tiina; Róg, Tomasz; Kankuri, Esko; Vilar, Marçal; Varjosalo, Markku; R Korpi, Esa; Permi, Perttu; S Mineev, Konstantin; Saarma, Mart; Vattulainen, Ilpo; C Casarotto, Plinio; Castrén, Eero

doi:10.1038/s41593-023-01316-5

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Psychedelics promote plasticity by directly binding to BDNF receptor TrkB.

Shared by NobleBlocks on Jun 1, 2023 • 12:00 AM UTC

Authors:

Rafael Moliner

Mykhailo Girych

Cecilia A Brunello

Abstract

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, including fluoxetine and ketamine, act by binding to TrkB, the receptor for B...

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