Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies
            <i>FIXER</i>
            , a Conserved Profibrogenic Long Noncoding RNA

Aghagolzadeh, Parisa; Plaisance, Isabelle; Bernasconi, Riccardo; A. Treibel, Thomas; Pulido Quetglas, Carlos; Wyss, Tania; Wigger, Leonore; Nemir, Mohamed; Sarre, Alexandre; Chouvardas, Panagiotis; Johnson, Rory; González, Arantxa; Pedrazzini, Thierry

doi:10.1161/circulationaha.122.062601

Public

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i> , a Conserved Profibrogenic Long Noncoding RNA

Shared by NobleBlocks on Aug 28, 2023 • 12:00 AM UTC

Authors:

Parisa Aghagolzadeh

Isabelle Plaisance

Riccardo Bernasconi

Abstract

BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis. Fibrosis is associated with heart dysfunction and failure. Myofibroblasts therefore repre...

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