Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

J Robertson, Shelly; Bedard, Olivia; L McNally, Kristin; Shaia, Carl; S Clancy, Chad; Lewis, Matthew; M Broeckel, Rebecca; I Chiramel, Abhilash; G Shannon, Jeffrey; L Sturdevant, Gail; Rosenke, Rebecca; L Anzick, Sarah; Forte, Elvira; Preuss, Christoph; N Baker, Candice; M Harder, Jeffrey; Brunton, Catherine; Munger, Steven; P Bruno, Daniel; B Lack, Justin; M Leung, Jacqueline; Shamsaddini, Amirhossein; Gardina, Paul; E Sturdevant, Daniel; Sun, Jian; Martens, Craig; M Holland, Steven; A Rosenthal, Nadia; M Best, Sonja

doi:10.1038/s41467-023-40076-5

Public

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

Shared by NobleBlocks on Jul 25, 2023 • 12:00 AM UTC

Authors:

Shelly J Robertson

Olivia Bedard

Kristin L McNally

Abstract

Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and clinical outcomes o...

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