PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Glaviano, Antonino; S. C. Foo, Aaron; Y. Lam, Hiu; C. H. Yap, Kenneth; Jacot, William; H. Jones, Robert; Eng, Huiyan; G. Nair, Madhumathy; Makvandi, Pooyan; Geoerger, Birgit; H. Kulke, Matthew; D. Baird, Richard; S. Prabhu, Jyothi; Carbone, Daniela; Pecoraro, Camilla; B. L. Teh, Daniel; Sethi, Gautam; Cavalieri, Vincenzo; H. Lin, Kevin; R. Javidi-Sharifi, Nathalie; Toska, Eneda; S. Davids, Matthew; R. Brown, Jennifer; Diana, Patrizia; Stebbing, Justin; A. Fruman, David; P. Kumar, Alan

doi:10.1186/s12943-023-01827-6

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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

Shared by NobleBlocks on Aug 18, 2023 • 12:00 AM UTC

Authors:

Antonino Glaviano

Aaron S. C. Foo

Hiu Y. Lam

Abstract

Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-inter...

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