EPCO-16. DISRUPTING DOT1L EPIGENETIC ACTIVITY REPROGRAMS GLIOBLASTOMA STEM CELLS TOWARDS A DOPAMINERGIC NEURONAL-LIKE STATE

Assaf, Samir; Bozek, Danielle; Artee Luchman, H.; Weiss, Samuel

doi:10.1093/neuonc/noad179.0479

Public

EPCO-16. DISRUPTING DOT1L EPIGENETIC ACTIVITY REPROGRAMS GLIOBLASTOMA STEM CELLS TOWARDS A DOPAMINERGIC NEURONAL-LIKE STATE

Shared by NobleBlocks on Nov 1, 2023 • 12:00 AM UTC

Authors:

Samir Assaf

Danielle Bozek

H. Artee Luchman

Abstract

Abstract Glioblastoma is the most common and aggressive primary adult brain tumor, remaining incurable despite current therapeutic strategies. Through a genome-wide essentiality screen, we previously identified disruptor of telomeric silencing-1-like (DOT1L) as one of the most important epigenetic r...

Subject

Epigenetics

Biology

Chromatin

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