A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage.

D, Kong; Y, He; J, Wang; L, Chi; X, Ao; H, Ye; W, Qiu; X, Zhu; M, Liao; H, Fan

doi:10.1080/22221751.2023.2287682

Public

A single immunization with H5N1 virus-like particle vaccine protects chickens against divergent H5N1 influenza viruses and vaccine efficacy is determined by adjuvant and dosage.

Shared by NobleBlocks on Dec 30, 2023 • 12:00 AM UTC

Authors:

Kong D

He Y

Wang J

Abstract

The H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on the insect cell-baculovirus expression system. Single imm...

Subject

Adjuvant

H5N1

virus-like particle

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