Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis.

Clabbers, Julia; Boesjes, Celeste; Spekhorst, Lotte; W van Gisbergen, Marike; Maas, Emmy; Marshall, Josephine; Janssen, Renske; Janssen, Miranda; Zuithoff, Nicolaas; Steijlen, Peter; de Graaf, Marlies; van Geel, Michel; de Bruin-Weller, Marjolein; Gostyński, Antoni

doi:10.1016/j.jaci.2023.12.027

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Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis.

Shared by NobleBlocks on Apr 1, 2024 • 12:00 AM UTC

Authors:

Julia Clabbers

Celeste Boesjes

Lotte Spekhorst

Abstract

BACKGROUND: Pathogenic variants in filaggrin (FLG) are associated with an increased risk of atopic dermatitis (AD). OBJECTIVE: We evaluated the influence of FLG variants on the effectiveness of dupilumab treatment in AD. METHODS: This prospective observational study included adult AD patients treate...

Subject

Atopic dermatitis

biologics

dupilumab

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