Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway

Wen, Xuewei; Li, Song; Zhang, Yanfei; Zhu, Liang; Xi, Xiaoting; Zhang, Shuyuan; Li, Yan

doi:10.6084/m9.figshare.19746487

Public

Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway

Shared by NobleBlocks on Jan 1, 2022 • 12:00 AM UTC

Authors:

Xuewei Wen

Song Li

Yanfei Zhang

Abstract

Globally, age-related macular degeneration (AMD) is a common irreversible ophthalmopathy. Oxidative stress of retinal pigment epithelial cells is involved in AMD occurrence and development. Klotho is an anti-aging protein with antioxidant properties. We investigated the protective properties of Klot...

Subject

PI3K/AKT/mTOR pathway

Protein kinase B

Hydrogen peroxide

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