Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development.

K, Weinhäupl; L, Meuret; S, Desrat; F, Roussi; N, Morellet; S, Beaupierre; C, Guillou; Heijenoort C, van; O, Abian; S, Vega; I, Wolf; T, Akopian; O, Krandor; E, Rubin; A, Velazquez-Campoy; D, Gauto; H, Fraga

doi:10.1038/s41598-025-87535-1

Public

Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development.

Shared by NobleBlocks on Feb 3, 2025 • 12:00 AM UTC

Authors:

Weinhäupl K

Meuret L

Desrat S

Abstract

MtbClpC1 is a promising drug target against tuberculosis. Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death. While the pharmacological properties of these natural product antibiotics preve...

Subject

Tuberculosis

Chaperone

In silico

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